Fermented biopolymers
Production of biopolymers (PHA, PHB) through microbial fermentation: biodegradable, bio-based bioplastics as a sustainable alternative to fossil-derived polymers.
The application
Polyhydroxyalkanoates (PHA) and polyhydroxybutyrate (PHB) are biopolymers accumulated by various microorganisms as carbon storage. They are biodegradable and represent a concrete alternative to petroleum-derived plastics.
Their production requires high-cell-density fermentations with feeding strategies designed to induce polymer accumulation. Our bioreactors provide the control and scalability needed to move the process from lab to pilot scale.
Technology involved
High-cell-density stirred-tank vessels with precise feeding and nutrient control, to maximise biopolymer yield.
- High-density fermentation. High biomass as the basis for consistent PHA/PHB accumulation.
- Fed-batch strategies. Controlled nutrient limitation to trigger and maximise polymer accumulation.
- Process control. Fine management of dissolved oxygen, pH and feeding through Bioflex™ recipes.
- Scalability. Consistent process transfer from bench to pilot scale on a single platform.
From research to production, one platform
The same parameters and Bioflex™ recipes carry you from bench to industrial scale, reducing transfer risk between stages.
Biobook Compact
Single-vessel benchtop screening and early development.
See system →Biobook Twin
Parallel studies and process optimisation on two vessels.
See system →Biosip
Transfer to 316L SIP/CIP stainless steel at pilot scale.
See system →Bioferm
Industrial GMP production with DQ/IQ/OQ/PQ documentation.
See system →Maximising PHA accumulation in fed-batch
Biopolymer produced
Process strategy
Renewable feedstock
This space will describe how a client optimised PHA accumulation in fed-batch: strain, feeding strategy and polymer yield on cell dry weight.
Placeholder text — we will add yield data, productivity and biopolymer properties once the case study is approved.
Let’s talk about your process
Tell us about your application: our engineering team replies within 24 hours.